Fowler served four prime ministers in a variety of posts, including President of the Local Government Board under Gladstone and Secretary of State for India under Rosebery. He represented Wolverhampton as Liberal MP for Wolverhampton 1880-85 and Wolverhampton East 1885-1908. In the 1890s Fowler, along with Asquith, Grey and Haldane, was one of Lord Rosebery’s key supporters and in 1902 he was a founder of the Liberal League. Fowler again held cabinet office from 1905-10 but age and ill health prevented him from playing a major role. He died in 1911 aged 80.